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Some of the biggest risk factors for B12 deficiency are vegetarian/vegan diets, pregnancy/breastfeeding, and aging

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Mild headaches for a week might be acceptable

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In general: If you follow a vegan, vegetarian, or low-meat diet and are not supplementing with vitamin B12 you might be at risk for deficiency

Additional preclinical work published in Cell Chemical Biology evaluated NNMT inhibition in similar diet-induced obesity models and confirmed the pattern: significant reductions in body weight gain, adipose tissue expansion, and circulating triglycerides compared to untreated controls